Pharmacophores and Pharmacophore Searches

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Pharmacophores and Pharmacophore...

Pharmacophores and Pharmacophore Searches

Name: Pharmacophores and Pharmacophore Searches
ISBN: 9783527312504

Thierry Langer, R?my D. Hoffmann, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers

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This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research.

Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties.

With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.

درجه (قاطیغوری(:

Medicine

کال:

2006

خپرندویه اداره:

Wiley-VCH

ژبه:

english

صفحه:

388

ISBN 10:

3527312501